Mendes reunited with Denzel Washington for the thriller Out of Time, in which she played the soon-to-be ex-wife of a well-respected chief of police. The film was a moderate commercial success, and Roger Ebert, in his review for the film, described Mendes' role as a "curiously forgiving character, who feels little rancor for the straying [husband] and apparently still likes him; maybe there would have been more suspense if she were furious with him". Her last 2003 film was the comedy Stuck on You, with Matt Damon and Greg Kinnear, in which she played an aspiring actress. She starred with Will Smith, as the love interest of a professional dating consultant, in her next film, Hitch (2005), making her one of the first minority actors to play the lead in a mainstream romantic comedy. USA Today described it as "her best screen role to date", and Detroit Free Press remarked: "Smith and Mendes are terrific together. He brings her game up so high you'd think she has had as many good parts as Smith". Hitch was the highest-grossing comedy in North America until 2018, and made US$368. 1 million in its global theatrical run. In 2005, Mendes also starred in the little-seen films The Wendell Baker Story and Guilty Hearts.