The series focuses on a rather self-centered, cocky adolescent American boy named "Mikey" who wins a starring role in a popular Japanese television series LilyMu by centering on a team of crime-fighters with personalities based around typical anime characters. He becomes acquainted with his co-stars, including Gonard, a tall, husky, sweet, rather dimwitted young man who portrays the primary antagonist of the LilyMu series, Lily, the spoiled, heartless portrayer of the otherwise ingenuous and sweet damsel-in-distress of LilyMu who contempts Mikey for having overtaken her limelight, Mitsuki, a sweet-natured actress infatuated with Mikey who plays a much tougher character in the series than in reality, and Guano, a small, fuzzy, purple creature with many insecurities, responsibilities, strange habits and tendencies. The program in which the actors are featured is run by a tyrannical, strict and loud boss named "Ozu" who is not only noted for his sour demeanor and constant infuriation with Mikey, but also his mentoring guidance, and aided by Yes-Man, his dedicated and trustworthy assistant who loyally upholds him and agrees with any decision that he makes. The series centers on the actors' daily lives aside from filming the television program and the predicaments in which they may entangle themselves at the hands of their own cockiness, incompetence, or celebrity status, and episodes usually feature sub-plots following the lives of whichever characters are not being primarily featured in that particular episode. The series relies heavily on gags and other things for comedy.