Doremi Harukaze/Dorie Goodwyn, a third grade elementary school girl living in the fictional Japanese town of Misora (the fictional American town of Port Mystic in the English dub), comes across an esoteric shop known as the Maho-Do (MAHO堂), accidentally discovering that its owner, Majo Rika, is a witch. Due to a curse placed on any witch whose identity is exposed by a human, Majo Rika is transformed into a magical frog. Wanting to return to her original form, Majo Rika makes Doremi her witch apprentice, giving her the ability to cast magic. Feeling guilty for placing that curse on her, Doremi accepts Majo Rika's offer in hopes of fixing her mistake. In order to become a fully fledged witch capable of turning Majo Rika back into a human, Doremi has to pass nine different witch tests, whilst also keeping her identity a secret from other humans. Doremi is soon joined by her two best friends, Hazuki Fujiwara/Reanne Griffith and Aiko Senoo/Mirabelle Haywood, and later by her younger sister Pop/Caitlyn who all become witch apprentices, helping to run the Maho-Do whilst using magic to help out their friends and families, with the occasional mishap. They soon come across a rival witch apprentice, Onpu Segawa/Ellie Craft, who has been using forbidden magic to influence people's memories. Whilst initially cold towards the other girls, Onpu soon warms up to them and sacrifices herself to prevent their identities from being revealed. In order to save Onpu from an eternal sleep, the girls give up their magic powers to awaken her.